Category: News

Amplification of long non-coding RNA ZFAS1 promotes metastasis in hepatocellular carcinoma

Despite progress in diagnostics and treatment of hepatocellular carcinoma (HCC), its prognosis remains poor. In this study, we globally assessed long non-coding RNAs (lncRNA) for contributions to HCC using publically available microarray data, in vitro...

microRNA-Mediated Network Regulation in Cancer

microRNAs (miRNA) are well suited to the task of regulating gene expression networks, because any given miRNA has the capacity to target dozens, if not hundreds, of genes. The simultaneous targeting of multiple genes within a pathway may enable miRNAs ...

Evaluation of NanoString Technologies nCounter Platform

Analysis of clinical trial specimens such as formalin-fixed paraffin-embedded (FFPE) tissue for molecular mechanisms of disease progression or drug response is often challenging and limited to a few markers at a time. This has led to the increasing imp...

An in vivo method to identify microRNA targets not predicted by computation algorithms: p21 targeting by miR-92a in cancer

microRNAs (miRNAs) dysregulation is involved in the development and progression of various human cancers, including hepatocellular carcinoma (HCC). However, how to identify the miRNAs targeting specific mRNA in cells is a significant challenge because ...

Identification of miR-92a Targeting p21 mRNA

microRNA (miRNA) dysregulation is involved in the development and progression of various human cancers, including hepatocellular carcinoma (HCC). However, how to identify the miRNAs targeting specific mRNA in cells is a significant challenge because of...