Category: News

Neuroendocrine Transdifferentiation and Prostate Cancer

Prostate cancer is highly sensitive to hormone therapy because androgens are essential for prostate cancer cell growth. However, with the nearly invariable progression of this disease to androgen independence, endocrine therapy ultimately fails to cont...

Neuroendocrine Transdifferentiation in Human Prostate Cancer Cells: An Integrated Approach

Prostate cancer (PCa) is highly sensitive to hormone therapy because androgens are essential for prostate cancer cell growth. However, with the nearly invariable progression of this disease to androgen independence (AI), endocrine therapy ultimately fa...

Intrinsic Inflammation and Immune Evasion in Cancer

Immune escape is a hallmark of cancer, but whether it relies upon extrinsic immune-selective pressure or is inherently orchestrated by oncogenic pathways is unresolved. To address this question, we took advantage of an in vitro model of sequentially tr...

Oncogenic transformation can orchestrate immune evasion and inflammation in human mesenchymal stem cells independently of extrinsic immune-selective pressure

Immune escape is a hallmark of cancer, but whether it relies upon extrinsic immune selective pressure or is inherently orchestrated by oncogenic pathways is unresolved. To address this question, we took advantage of an in vitro model of sequentially tr...

Amplification of long non-coding RNA ZFAS1 promotes metastasis in hepatocellular carcinoma

Despite progress in diagnostics and treatment of hepatocellular carcinoma (HCC), its prognosis remains poor. In this study, we globally assessed long non-coding RNAs (lncRNA) for contributions to HCC using publically available microarray data, in vitro...