Category: News

Different Functional Roles of TAZ/YAP in HCC

Transcriptional coactivator with PDZ-binding motif (TAZ) and yes-associated protein (YAP) are equivalently placed downstream effectors of the Hippo pathway with oncogenic roles in human cancers. However, the expression profiles of TAZ/YAP differ depend...

The PKC-NF{kappa}B Signaling Pathway Induces APOBEC3B Expression in Multiple Human Cancers

Overexpression of the antiviral DNA cytosine deaminase APOBEC3B has been linked to somatic mutagenesis in many cancers. HPV infection accounts for APOBEC3B upregulation in cervical and head/neck cancers, but the mechanisms underlying non-viral malignan...

Kinetic modeling and constrained reconstruction of hyperpolarized 1-13C-pyruvate offers improved metabolic imaging of tumors

Hyperpolarized 1-13C-pyruvate has shown tremendous promise as an agent for imaging tumor metabolism with unprecedented sensitivity and specificity. Imaging hyperpolarized substrates by magnetic resonance is unlike traditional MRI because signals are hi...

Modeling and Metabolic MRI with Hyperpolarized Pyruvate

Hyperpolarized [1-13C]-pyruvate has shown tremendous promise as an agent for imaging tumor metabolism with unprecedented sensitivity and specificity. Imaging hyperpolarized substrates by magnetic resonance is unlike traditional MRI because signals are ...

Osteogenic potential of mesenchymal stromal cells contributes to primary myelofibrosis

Primary myelofibrosis (PMF) is a myeloproliferative neoplasm which is a precursor to myeloid leukemia. Dysmegakaryopoiesis and extramedullary hematopoiesis characterize PMF, which is also associated with bone marrow (BM) stromal alterations marked by f...