Category: News

Jacquelyn’s Story

Jacquelyn Roth was diagnosed with breast cancer at just 28 years old. She writes about what it was like to be diagnosed at such a young age and how her perspective on life changed.

Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis

Fluorescent proteins are widely used to study molecular and cellular events, yet this traditionally relies on delivery of excitation light, which can trigger autofluorescence, photoxicity, and photobleaching, impairing their use in vivo. Accordingly, c...

Hypoxia-induced WSB1 promotes the metastatic potential of osteosarcoma cells

Intratumoral hypoxia occurs in many solid tumors where it is associated with the development of metastatic character. However, the connections between these phenomena are not fully understood. In this study we define an integrative role for the E3 ubiq...

WSB1 Promotes Osteosarcoma Metastasis

Intratumoral hypoxia occurs in many solid tumors, where it is associated with the development of metastatic character. However, the connections between these phenomena are not fully understood. In this study, we define an integrative role for the E3 ub...

An imbalance in TAZ and YAP expression in hepatocellular carcinoma confers cancer stem cell-like behaviors contributing to disease progression.

Transcriptional co-activator with PDZ-binding motif (TAZ) and yes-associated protein (YAP) are equivalently placed downstream effectors of the Hippo pathway with oncogenic roles in human cancers. However, the expression profiles of TAZ/YAP differ depen...