Focus on Cancer RSS Feed 2014-06-30 19:02:00

“When I came to the Abramson Cancer Center (ACC) with stage 2 synovial sarcoma, I needed hope and I needed help. Dr. Kristy Weber treated my cancer in a way no one else could. She saved my leg and my life. Thanks to the sarcoma program at the ACC, I am a three-month cancer survivor.”  Megan Dychala, sarcoma cancer survivor

Sarcoma at Penn

At 23, Megan Dychala was a former college soccer player who thought her nagging knee pain was a result of old injuries. She was young, active, and enjoying all that life had to offer her. But, in October, 2013 she got a phone call that would change her life.

Megan’s ongoing knee pain was in fact a tumor behind her knee. One day she was healthy and the next she was faced with a rare and aggressive cancer. Although statistics were against Megan, she knew she wouldn’t let anything happen without a fight.

Luckily Megan found Penn’s Abramson Cancer Center and Kristy Weber, MD. While other hospitals said that amputation was her only chance for survival, Dr. Weber knew she could do better – treating Megan’s cancer, but also ensuring a good quality of life after treatment.

Megan shares her personal journey at the Abramson Cancer Center below. 

My Sarcoma Story

My medical team worked with me to develop an aggressive treatment plan that included five and a half weeks of daily radiation followed by an intense surgery. Dr. Stephen Hahn was my rockstar of a radiation oncologist and took care of me every step of the way. Radiation left me burned and uncomfortable, but it is truly amazing how the skin recovers from so much trauma.

Finishing radiation and ringing the bell, surrounded by my family and the other cancer warriors there, was one of the best days of my life.

Sarcoma Penn

The surgery we opted for allowed me to keep my leg, but I would be sacrificing abilities. With so much reconstruction and working with nerves, there is no guarantee the leg will regain proper function. I was told I could never walk without a cane or walker and that I could need to wear a leg brace, possibly for the rest of my life, to support my foot. I was also told I could have limited mobility restricting things like driving and basic daily tasks.

The “what could bes” were daunting, but I trusted Dr. Weber and my vascular and plastic surgeon guru Dr. Stephen Kovach. Together, Drs. Weber and Kovach removed the back of my knee and rebuilt my leg through vascular, skin, and muscle grafts in a 14-hour surgery. I had a long road ahead of me, and a mountain of unknowns to climb.

Drs. Weber and Kovach’s work was phenomenal. Less than six weeks after surgery, I was walking on my own two feet. I never had to use a cane or walker. I don’t wear a leg brace. I drive my car, work out at the gym, and walk my dog. My leg function is improving everyday, and I see a 100 percent return in my future. This experience has taught me a lot, but most importantly, no matter how much the deck is stacked against you, or how grim the statistics look, you should always remember that you can be the one to improve the statistics.

A positive attitude goes an incredibly long way. I was diagnosed with a “one in a million cancer,” but now I am one more survivor. I owe this second chance at life to my amazing team at Penn Medicine and the Abramson Cancer Center.

Does caffeine fight cancer?

coffee-beans
Epidemiological studies have shown that caffeinated drinks may help prevent skin cancer by inhibiting a DNA repair pathway, thus killing potentially precancerous cells. In English, it means that drinking drinks containing caffeine will reduce one’s chances of developing some types of cancer, including UV-associated skin cancer. That just proves that caffeine fight cancer. The results, published in the Proceedings of the National Academy of Sciences, lend support to the idea that caffeine could be added to sunblock to increase its protective effects. At the cellular level, they’re showing that caffeine is working in this way of inducing an apoptotic mechanism. This statement was then made by cancer epidemiologist Joanne Kotsopoulos of the University of Toronto.

In the 2007, a study stated that woman who drank caffeinated coffee on a daily basis had a 10 percent lower risk of nonmelanoma skin cancer. Six or more cups of coffee a day translated to a 30 percent reduction in risk. Mouse studies have also confirmed the link, with both ingested and topically-applied caffeine lowering skin cancer rates in the animals. But exactly how the stimulant protected against cancer remained mysterious. One possibility is the drug’s inhibition of ataxia telangiectasia and Rad3-related (ATR), a large protein kinase that senses incomplete DNA replication often a result of DNA damage and signals the cell to not divide. By inhibiting ATR activity, caffeine could make cells more likely to die in response to UV damage, preventing damaged cells from ever becoming cancerous.

Studies have shown that the caffeine molecule acts as a sunscreen. It therefore blocks the penetration of UV rays. And that is why today we see many sunblocks with a good amount of caffeine in them.

Men’s Health Monday: Colorectal Cancer

Approximately 90 percent of colorectal cancers are thought to be preventable. Other than skin cancers, colorectal cancer is the third most common cancer diagnosis among men and women in the United States. Studies show that 1 in 20 Americans develop colorectal cancer during their lifetime.What is Colon Cancer?Colon cancer is the development of malignant tumors inan in the lining tissue of the colon. Most colon tumors begin when normal tissue forms a polyp, or pre-cancerous growth projecting from the wall of the colon. As the polyp grows, a tumor forms. Because the tumor grows slowly, early detection is possible through screening and tests.Colon cancer is often combined with rectal cancer, which appears in the last several inches of the colon, and can collectively be referred to as “colorectal cancer.”Risk Factors for Colon CancerSome risk factors for colorectal cancer include:Over the age of 50Personal history of colorectal polyps or colorectal cancerPersonal history of inflammatory bowel diseaseFamily history of colorectal cancerInherited syndromesFAP – familial adenomatous polyposisHNPCC – hereditary non-polyposis colon cancer also known as Lynch syndromeJuvenile polyposisPeutz-JegherMYH geneRacial and ethnic background – African Americans and Ashkenazi JewsLifestyle factorsDiet high in red meats and processed meatsPhysical inactivityObesitySmokingHeavy alcohol useType 2 diabetesScreening and Prevention of Colon CancerRegular screening exams such as colonoscopies can prevent colorectal cancer.  During colonoscopies, any abnormal cells that begin as polyps can be found and removed before they become cancerous. Screening can also result in early detection of colorectal cancer when it is highly curable.Screening for colorectal cancer should begin at age 50 for those with no identified risk factor other than age. People with a family history or other risk factors should talk to their doctor about starting screening when they are younger. If you have an early onset of colon polyps, colon cancer, or multiple family members with colon polyps or colon and uterine cancer, you should consider genetic counseling and testing. Genetic counselors can be contacted at Pennsylvania Hospital by calling 215-829-6528 or at the Hospital of the University of Pennsylvania by calling 215-349-8141.Make an appointment for a colonoscopy at Penn

Men's Health Monday: Colorectal Cancer

Approximately 90 percent of colorectal cancers are thought to be preventable. Read why it’s important to get screened here. 

Focus on Cancer RSS Feed 2014-06-30 10:00:00

Approximately 90 percent of colorectal cancers are thought to be preventable. Other than skin cancers, colorectal cancer is the third most common cancer diagnosis among men and women in the United States. Studies show that 1 in 20 Americans develop colorectal cancer during their lifetime.

What is Colon Cancer?

Colon CancerColon cancer is the development of malignant tumors inan in the lining tissue of the colon. Most colon tumors begin when normal tissue forms a polyp, or pre-cancerous growth projecting from the wall of the colon. As the polyp grows, a tumor forms. Because the tumor grows slowly, early detection is possible through screening and tests.

Colon cancer is often combined with rectal cancer, which appears in the last several inches of the colon, and can collectively be referred to as “colorectal cancer.”

Risk Factors for Colon Cancer

Some risk factors for colorectal cancer include:

  • Over the age of 50
  • Personal history of colorectal polyps or colorectal cancer
  • Personal history of inflammatory bowel disease
  • Family history of colorectal cancer
  • Inherited syndromes
    • FAP – familial adenomatous polyposis
    • HNPCC – hereditary non-polyposis colon cancer also known as Lynch syndrome
    • Juvenile polyposis
    • Peutz-Jegher
    • MYH gene
  • Racial and ethnic background – African Americans and Ashkenazi Jews
  • Lifestyle factors
    • Diet high in red meats and processed meats
    • Physical inactivity
    • Obesity
    • Smoking
    • Heavy alcohol use
    • Type 2 diabetes

Screening and Prevention of Colon Cancer

Regular screening exams such as colonoscopies can prevent colorectal cancer.  During colonoscopies, any abnormal cells that begin as polyps can be found and removed before they become cancerous. Screening can also result in early detection of colorectal cancer when it is highly curable.

Screening for colorectal cancer should begin at age 50 for those with no identified risk factor other than age. People with a family history or other risk factors should talk to their doctor about starting screening when they are younger.

If you have an early onset of colon polyps, colon cancer, or multiple family members with colon polyps or colon and uterine cancer, you should consider genetic counseling and testing. Genetic counselors can be contacted at Pennsylvania Hospital by calling 215-829-6528 or at the Hospital of the University of Pennsylvania by calling 215-349-8141.

Make an appointment for a colonoscopy at Penn