GNAQ and GNA11 are heterotrimeric G protein alpha subunits which are mutated in a mutually exclusive pattern in most cases of uveal melanoma, one of the most aggressive cancers. Here we introduce the first transgenic mouse model of uveal melanoma, whic...

Pancreatic ductal adenocarcinoma (PDAC) develops via an accumulation of various gene mutations. The mechanism underlying the mutations in PDAC development, however, is not fully understood. Recent insight into the close association between the mutation...

Pancreatic ductal adenocarcinoma (PDA) develops via an accumulation of various gene mutations. The mechanism underlying the mutations in PDA development, however, is not fully understood. Recent insight into the close association between the mutation p...

Keratins that are overexpressed selectively in human carcinomas may offer diagnostic and prognostic utility. In this study, we show how high expression of keratin-17 (K17) predicts poor outcome in cervical cancer patients, at early or late stages of di...

Keratins that are overexpressed selectively in human carcinomas may offer diagnostic and prognostic utility. In this study, we show that high expression of keratin-17 (K17) predicts poor outcome in patients with cervical cancer, at early or late stages...