Metastasis is a multistep process requiring cancer cell signaling, invasion, migration, survival and proliferation. These processes require dynamic modulation of cell surface proteins by endocytosis. Given this functional connection, it has been sugges...

The fibroblast growth factor receptor FGFR1 is a therapeutic target under investigation in multiple solid tumors and clinical trials of selective tyrosine kinase inhibitors (TKI) are underway. Treatment with single TKI represents a logical step towards...

Survival rates associated with pancreatic cancer remain dismal despite advancements in detection and treatment strategies. Genetically engineered mouse models of pancreatic tumorigenesis have gained considerable attention based on their ability to reca...

Disease relapse in cancer patients many years after clinical remission, often referred to as cancer dormancy, is well documented but remains an incompletely understood phenomenon on the biologic level. Recent reviews have summarized potential models th...

Intratumoral heterogeneity helps drive the selection for diverse therapy-resistant cell populations. In this study, we demonstrate the co-existence of two therapy-resistant populations with distinct properties that are reproducibly enriched under condi...