Breast cancer (BC) is associated with alterations in a number of growth factor and hormone-regulated signaling pathways. Mouse models of metastatic BC typically feature mutated oncoproteins that activate PI3K, Stat3, and Ras signaling, but the individu...

Breast cancer is associated with alterations in a number of growth factor and hormone-regulated signaling pathways. Mouse models of metastatic breast cancer typically feature mutated oncoproteins that activate PI3K, Stat3, and Ras signaling, but the in...

Tumor suppressor genes regulate cell growth and prevent spontaneous proliferation that could lead to aberrant tissue function. Deletions and mutations of these genes typically lead to progression through the cell-cycle checkpoints, as well as increased...

DNase I is a secreted enzyme whose function has been presumed to control “waste management” in the human system, by degrading DNA that leaks from dead and dying cells. Emerging studies have instead yielded evidence that DNase I plays a central role...

Childhood exposure to flea and tick products and other indoor insecticides is associated with an increased risk for leukemia and lymphoma, a new study has found