Category: News

PD-1 blunts the function of ovarian tumor-infiltrating dendritic cells by inactivating NF-KappaB

The PD-1:PD-L1 immune signaling axis mediates suppression of T cell-dependent tumor immunity. PD-1 expression was recently found to be upregulated on tumor-infiltrating murine (CD11c+CD11b+CD8-CD209a+) and human (CD1c+CD19-) myeloid dendritic cells (TI...

Cooperation of Oncogenic KRAS and PIK3CA in Lung Cancer

KRAS-activating mutations drive human non–small cell lung cancer and initiate lung tumorigenesis in genetically engineered mouse (GEM) models. However, in a GEM model of KRASG12D-induced lung cancer, tumors arise stochastically following a latency p...

PRC2 epigenetically silences Th1-type chemokines to suppress effector T cell trafficking in colon cancer

Infiltration of tumors with effector T cells is positively associated with therapeutic efficacy and patient survival. However, the mechanisms underlying effector T cell trafficking to the tumor microenvironment remain poorly understood in patients with...

Immunotargeting of antigen xCT attenuates stem-like cell behavior and metastatic progression in breast cancer

Resistance to therapy and lack of curative treatments for metastatic breast cancer suggest that current therapies may be missing the subpopulation of chemo- and radio-resistant cancer stem cells (CSC). The ultimate success of any treatment may well res...

The Inescapable Influence of Noncoding RNAs in Cancer

This report summarizes information presented at the 2015 Keystone Symposium on “MicroRNAs and Noncoding RNAs in Cancer.” Nearly two decades after the discovery of the first miRNA, the role of noncoding RNAs in developmental processes and the mechan...