Category: News

miR-30a Inhibits LOX Expression and Progression of Anaplastic Thyroid Cancer

Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies but its genetic drivers remain little understood. In this study, we report losses in expression of the microRNA miR-30a which is downregulated in ATC compared to differentiate...

PDGFR{alpha} and {beta} Play Critical Roles in Mediating Foxq1-Driven Breast Cancer Stemness and Chemoresistance

Many epithelial-mesenchymal transition (EMT)-promoting transcription factors have been implicated in tumorigenesis and metastasis, as well as chemoresistance of cancer. However, the underlying mechanisms mediating these processes are unclear. Here we r...

PDGFRs Mediate Foxq1-Promoted Chemoresistance

Many epithelial–mesenchymal transition (EMT)–promoting transcription factors have been implicated in tumorigenesis and metastasis as well as chemoresistance of cancer. However, the underlying mechanisms mediating these processes are unclear. Here,...

Macrophage-Dependent Metastasis in Zebrafish

Cancer metastasis can occur at early stages of tumor development due to facilitative alterations in the tumor microenvironment. Although imaging techniques have considerably improved our understanding of metastasis, early events remain challenging to ...

Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development

Cancer metastasis can occur at early stages of tumor development due to facilitative alterations in the tumor microenvironment. While imaging techniques have considerably improved our understanding of metastasis, early events remain challenging to stud...