Category: News

Role of ERBB3 in EGFR-Mutant Lung Adenocarcinomas

ERBB3, a member of the EGFR family of receptor tyrosine kinases, has been implicated in activation of the PI3K pathway in human lung adenocarcinomas driven by EGFR mutations. We investigated the contribution of ERBB3 to the initiation, progression, an...

SND1 acts downstream of TGF{beta}1 and upstream of Smurf1 to promote breast cancer metastasis

SND1 is an AEG-1/MTDH/LYRIC-binding protein that is upregulated in numerous human cancers where it has been assigned multiple functional roles. In this study, we report its association with the TGFβ1 signaling pathway which promotes epithelial-mesench...

TGF{beta}1-Regulated SND1 Promotes Metastasis through Smurf1

SND1 is an AEG-1/MTDH/LYRIC-binding protein that is upregulated in numerous human cancers, where it has been assigned multiple functional roles. In this study, we report its association with the TGFβ1 signaling pathway, which promotes epithelial–me...

Tumorigenic activity of Merkel cell polyomavirus T antigens expressed in the stratified epithelium of mice

Merkel cell polyomavirus (MCPyV) is frequently associated with Merkel cell carcinoma (MCC), a highly aggressive neuroendocrine skin cancer. Most MCC tumors contain integrated copies of the viral genome with persistent expression of the MCPyV large T (L...

Merkel Cell Polyomavirus T Antigen Expression in Murine Skin

Merkel cell polyomavirus (MCPyV) is frequently associated with Merkel cell carcinoma (MCC), a highly aggressive neuroendocrine skin cancer. Most MCC tumors contain integrated copies of the viral genome with persistent expression of the MCPyV large T (...