Prostaglandin E2 (PGE2) is a pro-inflammatory lipid modifier that promotes cancer growth. The hydroxyprostaglandin dehydrogenase 15-PGDH catalyzes oxidation of the 15(S)-hydroxyl group of PGE2, leading to its enzymatic inactivation. Therefore, 15-PGDH ...

Prostaglandin E2 (PGE2) is a proinflammatory lipid mediator that promotes cancer growth. The 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes oxidation of the 15(S)-hydroxyl group of PGE2, leading to its inactivation. Therefore, 15-PGDH induc...

Breast cancer is a heterogeneous disease characterized by varying response to therapeutic agents and significant differences in long-term survival. Thus there remains an unmet need for early diagnostic and prognostic tools and improved histological cha...

Breast cancer is a heterogeneous disease characterized by varying responses to therapeutic agents and significant differences in long-term survival. Thus, there remains an unmet need for early diagnostic and prognostic tools and improved histologic ch...

Although the lung is the most common metastatic site for cancer cells, biological mechanisms regulating lung metastasis are not fully understood. Using heterotopic and intravenous injection models of lung metastasis in mice, we found that IL-5, a cytok...