The Notch pathway plays multiple key roles in tumorigenesis, and its signaling components have therefore aroused great interest as targets for emerging therapies. Here, we show that inhibition of Notch, using a soluble receptor Notch1 decoy, unexpecte...

Considerable evidence suggests that pro-inflammatory pathways drive self-renewal of cancer stem-like cells (CSC), but the underlying mechanisms remain mainly undefined. Here we report that the let7 repressor LIN28B and its regulator IKKβ sustain cance...

Considerable evidence suggests that proinflammatory pathways drive self-renewal of cancer stem-like cells (CSC), but the underlying mechanisms remain mainly undefined. Here we report that the let7 repressor LIN28B and its regulator IKBKB (IKKβ) susta...

GPRC5A is a G-protein coupled receptor expressed in lung tissue but repressed in most human lung cancers. Studies in Gprc5a-/- mice have established its role as a tumor suppressor function in this setting, but its the basis for its role have been obscu...

GPRC5A is a G-protein–coupled receptor expressed in lung tissue but repressed in most human lung cancers. Studies in Gprc5a −/− mice have established its role as a tumor-suppressor function in this setting, but the basis for its role has been ob...