Cross-talk between tumor cells and their microenvironment is critical for malignant progression. Cross-talk mediators, including soluble factors and direct cell contact, have been identified, but roles for the interaction of physical forces between tu...
Category: News
Plk1- and HOTAIR-Mediated Degradation of SUZ12 and ZNF198
Oncogenic Fusion-Positive Lung Adenocarcinoma Development
This report delivers a comprehensive genetic alteration profile of lung adenocarcinomas (LADC) driven by ALK, RET, and ROS1 oncogene fusions. These tumors are difficult to study because of their rarity. Each drives only a low percentage of LADCs. Whole-exome sequencing and copy-number variation analyses were performed on a Japanese LADC cohort (n = 200) enriched in patients with fusions (n = 31, 15.5%), followed by deep resequencing for validation. The driver fusion cases showed a distinct profile with smaller numbers of nonsynonymous mutations in cancer-related genes or truncating mutations in SWI/SNF chromatin remodeling complex genes than in other LADCs (P < 0.0001). This lower mutation rate was independent of age, gender, smoking status, pathologic stage, and tumor differentiation (P < 0.0001) and was validated in nine fusion-positive cases from a U.S. LADCs cohort (n = 230). In conclusion, our findings indicate that LADCs with ALK, RET, and ROS1 fusions develop exclusively via their dependence on these oncogene fusions. The presence of such few alterations beyond the fusions supports the use of monotherapy with tyrosine kinase inhibitors targeting the fusion products in fusion-positive LADCs. Cancer Res; 75(11); 1–8. ©2015 AACR.
Cell-Cell Adhesion and Cytoskeleton Tension Drive Cell Aggregation
Join Penn at the Race for the Cure 5/10
The 25th Annual Komen Philadelphia Race for the Cure® is a Mother’s Day tradition benefiting breast cancer research, education, screening and treatment.
Twenty-five percent of the funds raised by Komen Philadelphia supports the Komen national research program--a peer reviewed cancer research program offering grants in areas such as diagnosis, treatment, public health, survivorship and prevention. The remainder of the funds raised are invested locally in programs like the PMBHI, which help provide access to care and education in our community – both enriching and saving lives.
25th Annual Komen Philadelphia Race for the Cure®
Mother’s Day, May 10, 2015
Eakins Oval/Philadelphia Museum of Art
5K Run/Walk & 1-Mile Fun Walk
Join us and help make a difference.v
Mother’s Day, May 10, 2015
Eakins Oval/Philadelphia Museum of Art
5K Run/Walk & 1-Mile Fun Walk
Join us and help make a difference.v
Interested in joining our team?
To join the official Penn Medicine Team, patients, friends and family are welcome to visit the official registration page online and follow the instructions.Race for the Cure Schedule:
7:00 AM: Opening Ceremony: 25th Celebration Extravaganza
8:15 AM: 5K Run Start
8:25 AM: 5K Walk / 1-Mile Fun Walk Start
Other ways to show your support.
Can’t make it on Mothers' Day? You can still support Penn Medicine’s team by making a donation to the team.If you have questions about joining or would like to tell us why you walk in the Susan G. Komen Race for the Cure, please email Amy Kleger or visit PennMedicine.org/PennRace4Cure