Category: News

Hepatocyte Hopping of Sorafenib-Glucuronide

Recently, an efficient liver detoxification process dubbed “hepatocyte hopping” was proposed on the basis of findings with the endogenous compound, bilirubin glucuronide. According to this model, hepatocytic bilirubin glucuronide can follow a liver...

Paracrine effect of NRG1 and HGF drives resistance to MEK inhibitors in metastatic uveal melanoma

Uveal melanoma (UM) patients with metastatic disease usually die within one year, emphasizing an urgent need to develop new treatment strategies for this cancer. MEK inhibitors improve survival in cutaneous melanoma patients but show only modest effica...

Resistance to Targeted Therapies

Uveal melanoma patients with metastatic disease usually die within one year, emphasizing an urgent need to develop new treatment strategies for this cancer. MEK inhibitors improve survival in cutaneous melanoma patients but show only modest efficacy in...

Correction: Metastasis-Associated Protein 1 Transgenic Mice: A New Model of Spontaneous B-cell Lymphomas

Correction: Identification of Pax5 as a Target of MTA1 in B-cell Lymphomas