Reciprocal interactions between tumor cells and their microenvironment vitally impact tumor progression. In this study, we show that GM-CSF produced by primary breast tumor cells induced the activation of plasmacytoid pre-dendritic cells (pDC), a cell ...

Adenoviruses have been clinically tested as anti-cancer therapies but their utility has been severely limited by rapid, systemic cytokine release and consequent inflammatory toxicity. Here we describe a new approach to tackling these dangerous side eff...

Adenoviruses have been clinically tested as anticancer therapies but their utility has been severely limited by rapid, systemic cytokine release and consequent inflammatory toxicity. Here, we describe a new approach to tackling these dangerous side eff...

Antibodies that block the interaction between programmed death ligand 1 (PD-L1) and PD-1 have shown impressive anti-tumor activity. Patients with tumors expressing PD-L1 are most likely to respond to this treatment. The aim of our study was to develop ...

Antibodies that block the interaction between programmed death ligand 1 (PD-L1) and PD-1 have shown impressive antitumor activity. Patients with tumors expressing PD-L1 are most likely to respond to this treatment. The aim of our study was to develop a...